Monday 1 September 2008

Glasvegas 'shocked' by Britain's knife culture

Glasvegas frontman James Allan has admitted feeling disillusioned over the knife criminal offence culture which is currently sweeping the UK.


The singer has admitted that every time he reads about a wounding it "strikes" him with "total shock".


He said: "I guess there's a large list of potential roots to the problem. There are emphatically frustrations in the youth which experience been in our finish for quite a spell.


"But no matter how many times you read about it, it strikes you with total shock, the lack of human beings. Or like I say in (record album track) 'Ice Cream Van' 'pure community, freedom of faith, act of citizenship'.


"You recognize, there's no-one's actually expression, 'Grow a heart, man'. How could you actually harm another person? What's happening to us man?"


The singer, whose band's forthcoming debut record album features the track 'Flowers & Football Tops', which is lyrically inspired by the slay of a 15-year-old Glaswegian who was abducted close James's home, stabbed 13 times and drenched in petrol, aforesaid knife criminal offence was coarse in his hometown.


He told The Guardian: "It's been in the news a lot in London, merely in Glasgow it's always been like that. If you uprise up in Glasgow, you've been chased with something. I've been chased with a five iron!"


Between April 2007 and March 2008 up to 7,409 knife crime attacks were reported in London alone.



More info

Tuesday 12 August 2008

Molecule CX717 Has Positive Effects In Opiate-Induced Respiratory Depression In A Phase IIa Clinical Study

�Cortex Pharmaceuticals, Inc. (AMEX:
COR - News) reported that top-line data from its number one Phase IIa
study in opiate-induced respiratory depression (RD) demonstrated that
a single oral superman of 2100mg of AMPAKINE� CX717 achieved statistical
significance over placebo on the primary terminus measure. These
results are being presented at the Bank of Montreal Capital Markets
Focus on Healthcare Conference in New York City on Wednesday morning,
August 6, 2008 at 9:30AM (EDT) by Dr. Roger G. Stoll, President & CEO
of Cortex. This placebo controlled, double blind, randomized bipartite
crossover trial (RD-02) was performed by Parexel's clinical research
unit in Europe. In this study, eight (8) volunteers per cupid's disease group
each received either 900mg, 1500mg, or 2100mg of CX717 or matching
placebo that was by word of mouth administered two hours before each bailiwick
received an intravenous infusion of the opiate agonist, alfentanil.
The primary performance measures were derived from a CO2 re-breathing
procedure that measured the ventilation response of the subject to
increased CO2 levels in the presence of alfentanil. The primary
bar, the instant expiratory volume (VE) at 55mgHg CO2 (VE55), was
reversed by 2100 mg CX717 in comparison to placebo (p


No reliable responses were seen in the 900mg and 1500mg CX717 groups,
only procedural problems were detected by the Data Safety Monitoring
Board (DSMB) for this study, which was authorized by the protocol to
monitor safety and responses on an interim basis. Corrective
procedural changes were instituted before the initiation of the net
group of subjects in the 2100mg segment of the study.



"While we initiated this study victimisation oral doses of CX717 and had only
eight subjects per treatment chemical group, we were pleased to obtain
statistical significance using such small study groups," said Dr.
Roger Stoll the CEO of Cortex. The primary objective was to but
verify that the chemical mechanism, which was seen operation in animate being
studies, would also be operative in humans. Substantial investments
were required to develop an intravenous dose form of CX717,
including formulation developing and stability studies for such a
dosage form as well as deuce species toxicology trials. The Company now
feels that it lavatory proceed with such studies. Cortex latterly received
confirmation of three months of accelerated stability for the
experimental intravenous formulation of CX717 and plans to initiate
toxicology trials in the fourth quarter 2008.



A second respiratory depression study has been performed by a group
in Frankfurt, Germany. This study uses a single cupid's itch of 1500mg of
CX717 and focuses on both the respiratory depression and the
pain pill effects associated with alfentanil. The analysis of the
data has been initiated and related to results should be reported within
a few weeks. Studies of CX717 in animal models by Dr. John Greer at
the University of Alberta ingest shown that the AMPAKINE drugs do not
interfere with the analgesic personal effects of opiates.



Cortex continues to advance other AMPAKINE compounds, specially
those newer compounds that have potential difference patent lives to 2028. It
will also be reported at the BMO Capital Markets conference that
Cortex has initiated human phase one safety and kinetic trials with
CX1739 in normal volunteers. Assuming successful Phase I human trials
with this compound, the Company plans to rapidly pursue the Attention
Deficit-Hyperactivity disorder indication for CX1739 in the second
half of 2009. The Company will also written report on an initial creature trial
with CX1942, a unique pro-drug analog of another humbled impact AMPAKINE
drug that is highly water soluble, ideally suited for an intravenous
dosage form. This compound speedily hydrolyzes to the parent AMPAKINE
drug in vivo. CX1942 has shown exceptionally rapid results in
reversing respiratory low due to intravenously administered
fentanyl in rats. The Company plans to initiate toxicology studies
with this unique parallel during the last quarter of 2008.



High impact AMPAKINE compounds from recent patent applications are
as well being ripe with a focus on neurodegenerative diseases, such
as Alzheimer's and Parkinson's diseases, as easily as orphan drug
indications like Huntington's and Fragile X disease.



The conference presentation roved for the discussion of whatsoever disease. Cortex
disclaims any intent or obligation to update whatsoever forward-looking
statements.

Cortex Pharmaceuticals, Inc.


More info

Wednesday 6 August 2008

Endoscopic Circumferential Ablation Promising For Barrett's Esophagus With High-Grade Dysplasia

�A multicenter U.S. register study examining the treatment of Barrett's esophagus (BE) with high-grade dysplasia (HGD) showed that in 92 patients treated with endoscopic circumferential ablation who had at

Nihill

Nihill   
Artist: Nihill

   Genre(s): 
Metal: Death,Black
   



Discography:


Krach   
 Krach

   Year: 2007   
Tracks: 6




 





Luis Vargas

Noctes

Noctes   
Artist: Noctes

   Genre(s): 
Metal: Death,Black
   



Discography:


Vexilla Regis Prodeunt Inferni   
 Vexilla Regis Prodeunt Inferni

   Year: 1999   
Tracks: 11


Pandemonic Requiem   
 Pandemonic Requiem

   Year: 1997   
Tracks: 11




 






Thursday 3 July 2008

Sandalinas

Sandalinas   
Artist: Sandalinas

   Genre(s): 
Metal: Heavy
   



Discography:


Living On The Edge   
 Living On The Edge

   Year: 2005   
Tracks: 10




 





The Five Stars to Watch This Summer

Lousie Attaque

Lousie Attaque   
Artist: Lousie Attaque

   Genre(s): 
Other
   



Discography:


A Plus Tard Crocodile   
 A Plus Tard Crocodile

   Year:    
Tracks: 18